LCjoin               package:apComplex               R Documentation

_C_o_m_p_u_t_e_s _c_h_a_n_g_e _i_n _L_x_C _m_e_a_s_u_r_e

_D_e_s_c_r_i_p_t_i_o_n:

     Computes the change in the P=LxC measure for AP-MS protein data
     when two protein complex estimates are combined into one complex.

_D_e_t_a_i_l_s:

     These functions are used to evaluate changes in the penalized
     likelihood  when two complexes are combined.  They are not meant
     to be directly used.

_V_a_l_u_e:

     The numeric value of the change in P=LxC when two complexes are
     combined.

_A_u_t_h_o_r(_s):

     Denise Scholtens

_R_e_f_e_r_e_n_c_e_s:

     Scholtens D and Gentleman R.  Making sense of high-throughput
     protein-protein interaction data.  Statistical Applications in
     Genetics and Molecular Biology 3, Article 39 (2004).

     Scholtens D, Vidal M, and Gentleman R.  Local modeling of global
     interactome networks.  Bioinformatics 21, 3548-3557 (2005).

_S_e_e _A_l_s_o:

     'bhmaxSubgraph','mergeComplexes','findComplexes'

_E_x_a_m_p_l_e_s:

     data(apEX)
     PCMG0 <- bhmaxSubgraph(apEX)
     PCMG1 <- mergeComplexes(PCMG0,apEX,sensitivity=.7,specificity=.75)

