ppipred               package:y2hStat               R Documentation

_P_r_o_t_e_i_n-_p_r_o_t_e_i_n _p_r_e_d_i_c_t_i_o_n_s

_D_e_s_c_r_i_p_t_i_o_n:

     The data in 'ppipred' are those provided by Liu et al for S.
     cervisiae protein protein interactions.

_U_s_a_g_e:

     data(ppipred)

_F_o_r_m_a_t:

     A data frame with 20088 observations on the following 3 variables.

     '_G_e_n_e_1' A vector of the gene names for one interactor.

     '_G_e_n_e_2' A vector of the gene names for the other interactor.

     '_P_r_o_b_a_b_i_l_i_t_y' A vectror containing the probability they give to
          the interaction.

_D_e_t_a_i_l_s:

     Liu et al discuss a method for estimating protein-protein
     interactions from existing data, across species. They have
     provided the data with the following description: "We compute
     domain-domain interaction probabilities from Y2H  protein-protein
     interactions, and then use these domain-domain interaction 
     probabilities to compute the interaction probability between every
     pair  of proteins. The prediction results with a false positive
     rate fp=3E-4 and  a false negative rate fn=0.85 are listed blow."

_S_o_u_r_c_e:

     <URL: http://bioinformatics.med.yale.edu/interaction/>

_R_e_f_e_r_e_n_c_e_s:

     _Inferring protein-protein interactions through high-throughput 
     interaction data from diverse organisms_, Y. Liu, N. Liu and H.
     Zhao, Bioinformatics, 2005, 21, 3279-3285.

_E_x_a_m_p_l_e_s:

     data(ppipred)

