inNucleus {y2hStat} | R Documentation |
A function to determine those proteins annotated by the nucleus
GO term.
Description
This function takes the experimental y2h data as well as an estimate for
an in silico interactome (ISI) and determines which protein complexes of
the ISI has more than 75 percent of the constituent member proteins
annotated by the nucleus GO term.
Usage
inNucleus(y2h, ISI = NULL)
Arguments
y2h |
A three tiered list. Names of the second tier corresponds to
ID of experiment. Names of the third tier should be the bait
proteins. The entries of the third tier are character vectors of
proteins detected as prey |
ISI |
The incidence matrix of the bi-partite graph representation
of the in silico interactome. |
Value
nucProt |
A character vector of those proteins annotated to the nucleus |
nucComp |
An incidence matrix of the bipartite graph
representation of the ISI with the restriction that only complexes
with 75 percent of its constituent members are annnotated by the
nucleus term. |
nuclearY2H |
A data structure exactly like the input y2h, except
that the prey proteins are restricted to those which are annotated
by the nucleus term |
Author(s)
T Chiang
Examples
data(y2hSysGW)
eg=y2hSysGW[3]
inNucleus(eg)
[Package
y2hStat version 1.2.0
Index]